Make high school science review more engaging with this health science escape room about COVID-19, SARS-CoV-2, disease transmission, exponential growth, and public-health decision-making. Students work independently or in teams to read scientific information, analyze clues, watch videos, and solve digital locks. A teacher guide, answer key, differentiation options, and built-in timed hints are included.

Students investigate:

- SARS-CoV-2 and COVID-19
- Characteristics of human coronaviruses
- How infectious diseases are identified and studied
- Exponential growth and disease spread
- Hygiene and respiratory-virus prevention
- Vaccine development and evidence-based treatment
- Lessons from the 1918 influenza pandemic
- How scientific understanding changes with new evidence

How it works:

Students use an internet-connected device to open the website-based game, examine readings and videos, and enter a code for each challenge. Hints appear after five, ten, and twelve minutes, supporting students without immediately revealing answers. Use the activity for high school biology, health science, public health, infectious-disease units, epidemiology introductions, review, enrichment, collaborative problem-solving, or sub plans.

Included:

- Access to the digital escape game through Genially
- Complete teacher guide
- Answer key
- Built-in student hints
- Options for shortening or differentiating the game

Currency and technology note: Scientific and public-health information changes over time; the activity and external links were last reviewed in July 2026. Test links on your district network before assigning because filters may block individual sources. This classroom resource does not provide personal medical advice, and students should not enter personal health information.