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DNA, Genes, and Mutations Lesson - Middle School | MS–LS3-1 | Sickle Cell Anemia
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DNA, Genes, and Mutations Middle School - This Introductory Biology lesson is specifically designed for Middle School science and covers the NGSS MS–LS3-1 Standard. It is meant to be done over 2-3 days. It describes why structural changes to genes (mutations) located on chromosomes may affect proteins and may result in harmful, beneficial, or neutral effects to the structure and function of the organism.

The lesson content includes:

  • What DNA and chromosomes are
  • What genes are
  • Common genetic features
  • What proteins are
  • How does changing DNA change proteins
  • Mutations - what they are and what causes them
  • Mutations - harmful, beneficial, or neutral effects
  • Sickle cell anemia

Buyer Comments:

⭐️⭐️⭐️⭐️⭐️ Extremely satisfied "Thanks so much for creating such a useful resource!"

⭐️⭐️⭐️⭐️⭐️ Extremely satisfied "This was so fun and easy to use. Will definitely use again."


The focus of the lesson is the understanding that changes in genetic material may result in making different proteins. which leads to mutations but does not include specific changes at the molecular level, mechanisms for protein synthesis, or specific types of mutations.

NGSS: The material is all explained at the appropriate level using simplified terminology and examples. The emphasis is on the law of conservation of matter using physical models and drawings. It does not include specific changes at the molecular level, mechanisms for protein synthesis, or specific types of mutations.

This lesson package includes the lesson (student and teacher versions), SIX embedded videos, lots of good colorful diagrams, a student lesson handout as a document, and an auto-graded, 4-question Exit Ticket via Google Forms.

Included in the lesson package:

  • The teacher version of the presentation
  • The student version of the presentation
  • SIX embedded videos
  • An auto-graded Exit Ticket
  • Student lesson handout

The student version of the presentation contains multiple blanks that need to be filled in throughout the lesson. These blanks are conveniently underlined and bolded on the teacher copy. I have found this to be the most effective means of keeping my students engaged and active without having them write everything out. This also leaves more time for discussion and activities.

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Google and Distance Learning Ready

  • This lesson includes both Office and Google formats for ALL resources. The presentation is in PowerPoint and Google Slides while all documents contain Word and Google Doc versions.
  • Your resource is perfect for distance learning and integrates seamlessly with Google Classroom as I've included a link that will automatically create a copy of the resources and put them directly into your Google Drive with one click.
  • Purchase --> Open --> Click --> Assign to your students

Having both options allows you to use either without worrying about formatting issues as all the work has already been done for you. It safeguards you in case your department or school decides to go Google 100% and allows you as well as your students to access everything no matter where you are or what kind of equipment is being used.

Exit Ticket

Included in your package is an Exit Ticket which can be directly accessed from the last Google Slide. Additionally, your purchase will create a copy of the Google Form Exit Ticket which you can edit to meet your class needs.

I also have a range of assignments and lessons/units from other grade levels at my store. Please CLICK HERE to have a look around and don’t forget to follow if you like what you see.

Also, please visit my blog Teach With Fergy for my thoughts on teaching, learning, and everything in between.

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Meet the Seller

Middle and High School Science Engaging Resources

I have been selling resources to middle and high school teachers for the last 15 years. During that time I've also been in the classroom so I know what works and what will help your students the most.

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