10th Grade General Science Resources

The Antibiotic Resistance Mystery – Detective SUB PLAN | Bacteria, Germ Theory

Created by
TWFScience

The Antibiotic Resistance Mystery - Turn your students into science detectives with this engaging, real-world investigation focused on antibiotic resistance and what happens when bacterial infections no longer respond to treatment. In this case file activity, students analyze medical and laboratory

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Oxygen Delivery Crisis Mystery – Detective SUB PLAN | Human Body System

Created by
TWFScience

The Oxygen Delivery Crisis Mystery – Turn your students into science detectives with this engaging, real-world investigation focused on oxygen delivery in the human body and what happens when oxygen fails to reach cells efficiently—even when breathing appears normal. In this case file activity, stud

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Substance Abuse Impact on Body Systems Mystery – Detective SUB PLAN Activity

Created by
TWFScience

The Substance Abuse & Impact on Body Systems Mystery – Turn your students into science detectives with this engaging, real-world investigation focused on substance use and how vaping, smoking, and alcohol affect multiple body systems. In this case file activity, students analyze medical and labo

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

Human Body Systems and Health Detective Mystery Bundle | Activity SUB PLAN

Created by
TWFScience

Build a high-engagement, low-prep human body system and health program that grows with you. This bundle collects my Human Body Systems and Health Detective Mystery Case Files—each one built around real-world body system and health problem, evidence analysis, pathway tracking, suspect ranking, and Cl

7th - 11th Anatomy, Biology, General Science

The Blood Sugar Balance Mystery – Detective SUB PLAN | Insulin, Cells, Pancreas

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on health and blood glucose balance. In this case file activity, students analyze medical data, examine laboratory test results, track hormone pathways, interrogate suspects, and build a scientif

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Foodborne Illness Outbreak Mystery – Detective SUB PLAN | Salmonella

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on foodborne illness and digestive system infection. In this case file activity, students analyze medical data, examine laboratory test results, track pathogen pathways, rank possible causes, and

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Musculoskeletal System Injury Mystery – Detective SUB PLAN | Bones, Tendons

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on musculoskeletal system injuries and movement breakdown. In this case file activity, students analyze strength test data, examine range-of-motion measurements, investigate posture assessments,

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Nutrition & Diet Health Mystery – Detective SUB PLAN | Vitamins, Minerals

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on nutrition, diet, and whole-body health balance. In this case file activity, students analyze medical data, examine laboratory test results, track nutrient pathways, rank possible causes, and b

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Sleep Deprivation Health Mystery – Detective SUB PLAN | Circadian Rhythm

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on sleep deprivation and whole-body health disruption. In this case file activity, students analyze sleep logs, examine laboratory test results, track hormone pathways, rank possible causes, and

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Autoimmune Disorder Mystery – Detective SUB PLAN | Immunity, Body Systems

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on immune system malfunction and autoimmune disorders. In this case file activity, students analyze laboratory data, examine inflammatory markers, evaluate antibody test results, track immune pat

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Blood Types Mystery – Detective SUB PLAN | ABO, Rh factor, Body Systems

Created by
TWFScience

Create a classroom full of science detectives with this NO PREP, engaging, real-world investigation focused on blood types, transfusion compatibility, and immune system response. In this case file activity, students analyze laboratory results, examine transfusion reactions, track antibody pathways,

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Dehydration & Electrolyte Imbalance Mystery – Detective SUB PLAN

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on hydration, electrolyte balance, and whole-body system stability. In this case file activity, students analyze medical data, examine laboratory test results, track fluid and electrolyte pathway

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Immune System Breakdown Mystery – Detective SUB PLAN | Body Systems

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on immune system breakdown and whole-body health disruption. In this case file activity, students analyze laboratory reports, examine white blood cell counts, track stress hormone patterns, evalu

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Screen Time Addiction & Mental Health Mystery – Detective SUB PLAN |

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on screen time addiction and mental health disruption. In this case file activity, students analyze daily screen use data, examine dopamine reward responses, track sleep hormone disruption, evalu

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

When Will I Ever Use This? Reading | Grade 8 & Up | Solving Problems, Careers

Created by
TWFScience

Why We Need to Learn Science: Real-World Problem Solving, Careers, and Skilled Trades Reading Comprehension Passage and QuestionsThis reading answers the question we all get, "When am I ever Going to Use this?" This is a high-interest, real-world reading that helps students understand how science cl

8th - 12th Science, General Science, Physical Science

Also included in: Science Reading Comprehension Article Mega Bundle | Grade 8 and Up

The Acid Rain Mystery – Chemistry Detective Activity | Precipitation, pH scale

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on air pollution and chemical reactions in the atmosphere. In this case file activity, students analyze rainwater pH data, examine surface damage on stone buildings, evaluate plant health pattern

6th - 10th Chemistry, General Science, Physical Science

NGSS MS-PS1-1, MS-PS1-2, MS-PS1-3+3

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Household Cleaning Products Reaction Mystery – Chemistry Detective Activity

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on how household cleaning products work at the chemistry level. In this case file activity, students analyze cleaning test results, compare grease and stain removal data, evaluate disinfectant cl

6th - 10th Chemistry, General Science, Physical Science

NGSS MS-PS1-1, MS-PS1-2, MS-PS1-3+3

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Conductivity Case Mystery – Chemistry Detective Activity | Current, Circuit

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on why some liquids conduct electricity while others do not. In this case file activity, students analyze conductivity test results, compare salt water, sugar water, vinegar, baking soda, tap wat

6th - 10th Chemistry, General Science, Physical Science

NGSS MS-PS1-1, MS-PS1-2, MS-PS1-3+3

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Energy Release Mystery – Chemistry Detective Activity | Exothermic, Reaction

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on how and why some chemical reactions release energy rapidly. In this case file activity, students analyze temperature changes, observe gas production, evaluate reaction speed data, examine syst

6th - 10th Chemistry, General Science, Physical Science

NGSS MS-PS1-1, MS-PS1-2, MS-PS1-3+3

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Phase Change Puzzle Mystery | Detective Activity | States of Matter

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on why matter changes state without changing its identity. In this physical change vs chemical change case file activity, students analyze melting and freezing, evaporation, and condensation obse

6th - 10th Chemistry, General Science, Physical Science

NGSS MS-PS1-1, MS-PS1-2, MS-PS1-3+3

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Missing Mass Mystery - Chemistry Detective Activity | Conservation of Mass

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on the Law of Conservation of Mass. In this case file activity, students analyze mass measurements, examine gas formation data, compare open and closed systems, evaluate dissolving observations,

6th - 10th Chemistry, General Science, Physical Science

NGSS MS-PS1-1, MS-PS1-2, MS-PS1-3+3

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Ozone Layer Mystery - Chemistry Detective Activity | Ultraviolet Radiation

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on what protects Earth from harmful radiation. In this case file activity, students analyze UV radiation data, examine ozone concentration trends, evaluate atmospheric chemistry evidence, track h

6th - 10th Chemistry, General Science, Physical Science

NGSS MS-PS1-1, MS-PS1-2, MS-PS1-3+3

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Plastic Breakdown Mystery - Chemistry Detective Activity | Microplastics

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on why plastic lasts so long in the environment. In this case file activity, students analyze environmental observations, examine sunlight exposure data, compare decomposition patterns, evaluate

6th - 10th Chemistry, General Science, Physical Science

NGSS MS-PS1-1, MS-PS1-2, MS-PS1-3+3

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Solubility Surprise Mystery - Chemistry Detective Activity | Solute, Solvent

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on why some substances dissolve while others do not. In this case file activity, students analyze dissolving observations, examine temperature effects, compare different substances in water, eval

6th - 10th Chemistry, General Science, Physical Science

NGSS MS-PS1-1, MS-PS1-2, MS-PS1-3+3

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science