High School Science Resources

The Cellular Respiration Breakdown Mystery – Detective SUB PLAN | Body Systems

Created by
TWFScience

The Cellular Respiration Breakdown Mystery - Turn your students into science detectives with this engaging, real-world investigation focused on cellular respiration and what happens when cells cannot produce enough energy to meet the body’s needs. In this case file activity, students analyze medical

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Stress Response & Health Breakdown Mystery – Detective SUB PLAN | Systems

Created by
TWFScience

The Stress Response & Health Breakdown Mystery - Turn your students into science detectives with this engaging, real-world investigation focused on the human stress response and what happens when stress becomes chronic. In this case file activity, students analyze medical evidence, track hormone

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Integumentary System Disorder Mystery – Detective SUB PLAN | Body Systems

Created by
TWFScience

The Integumentary System Disorder Mystery - Turn your students into science detectives with this engaging, real-world investigation focused on the integumentary system and what happens when the skin can no longer protect the body or regulate temperature effectively. In this case file activity, stude

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Respiratory System Failure Mystery – Detective SUB PLAN | Human Body Systems

Created by
TWFScience

The Respiratory System Failure Mystery - Turn your students into science detectives with this engaging, real-world investigation focused on the respiratory system and what happens when breathing and gas exchange break down. In this case file activity, students analyze medical evidence, track respira

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Antibiotic Resistance Mystery – Detective SUB PLAN | Bacteria, Germ Theory

Created by
TWFScience

The Antibiotic Resistance Mystery - Turn your students into science detectives with this engaging, real-world investigation focused on antibiotic resistance and what happens when bacterial infections no longer respond to treatment. In this case file activity, students analyze medical and laboratory

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Oxygen Delivery Crisis Mystery – Detective SUB PLAN | Human Body System

Created by
TWFScience

The Oxygen Delivery Crisis Mystery – Turn your students into science detectives with this engaging, real-world investigation focused on oxygen delivery in the human body and what happens when oxygen fails to reach cells efficiently—even when breathing appears normal. In this case file activity, stud

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Substance Abuse Impact on Body Systems Mystery – Detective SUB PLAN Activity

Created by
TWFScience

The Substance Abuse & Impact on Body Systems Mystery – Turn your students into science detectives with this engaging, real-world investigation focused on substance use and how vaping, smoking, and alcohol affect multiple body systems. In this case file activity, students analyze medical and labo

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

Human Body Systems and Health Detective Mystery Bundle | Activity SUB PLAN

Created by
TWFScience

Build a high-engagement, low-prep human body system and health program that grows with you. This bundle collects my Human Body Systems and Health Detective Mystery Case Files—each one built around real-world body system and health problem, evidence analysis, pathway tracking, suspect ranking, and Cl

7th - 11th Anatomy, Biology, General Science

Earth Day Countdown | 22 Environmental Science Starter Slides | Earth Day Warmup

Created by
TWFScience

Earth Day Countdown – Class Starter Discussion Slides & Teacher Guide. 22 Days of Discussion and Collaboration. Fully editable.Looking for an engaging way to spark meaningful conversations about environmental issues leading up to Earth Day or just how humans impact the environment? This Earth Da

6th - 11th Biology, Earth Sciences, Marine Science

NGSS MS-LS2-1, MS-LS2-4, MS-ESS3-1+9

Earth Day Countdown | Environmental Class Starter 3-DAY SAMPLE

Created by
TWFScience

Earth Day Countdown SAMPLE – Class Starter Discussion Slides & Teacher Guide. 3 Days of Discussion and Collaboration. The full version - Earth Day Countdown | 22 Environmental Class Starter Slides for Discussion and Collaboration can be found by clicking here.The full version contains 22, fully

6th - 11th Biology, Earth Sciences, Marine Science

NGSS MS-LS2-1, MS-LS2-4, MS-ESS3-1+9

Air Pollution Reading | High School | Sources, Pollutants, Smog Chemistry

Created by
TWFScience

Air Pollution - Sources, Pollutants, Smog Chemistry, AQI, and Solutions Reading Comprehension Passage and Questions. This high school reading introduces students to the science of air pollution, explaining how pollutants are released, how they change in the atmosphere, and how they affect human heal

9th - 12th Science, Earth Sciences, Physical Science

Also included in: Human Impact & Sustainability - 13 Reading Comprehension Bundle | Grade 8 and Up

The Blood Sugar Balance Mystery – Detective SUB PLAN | Insulin, Cells, Pancreas

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on health and blood glucose balance. In this case file activity, students analyze medical data, examine laboratory test results, track hormone pathways, interrogate suspects, and build a scientif

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Foodborne Illness Outbreak Mystery – Detective SUB PLAN | Salmonella

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on foodborne illness and digestive system infection. In this case file activity, students analyze medical data, examine laboratory test results, track pathogen pathways, rank possible causes, and

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Musculoskeletal System Injury Mystery – Detective SUB PLAN | Bones, Tendons

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on musculoskeletal system injuries and movement breakdown. In this case file activity, students analyze strength test data, examine range-of-motion measurements, investigate posture assessments,

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Nutrition & Diet Health Mystery – Detective SUB PLAN | Vitamins, Minerals

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on nutrition, diet, and whole-body health balance. In this case file activity, students analyze medical data, examine laboratory test results, track nutrient pathways, rank possible causes, and b

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Sleep Deprivation Health Mystery – Detective SUB PLAN | Circadian Rhythm

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on sleep deprivation and whole-body health disruption. In this case file activity, students analyze sleep logs, examine laboratory test results, track hormone pathways, rank possible causes, and

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Autoimmune Disorder Mystery – Detective SUB PLAN | Immunity, Body Systems

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on immune system malfunction and autoimmune disorders. In this case file activity, students analyze laboratory data, examine inflammatory markers, evaluate antibody test results, track immune pat

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Blood Types Mystery – Detective SUB PLAN | ABO, Rh factor, Body Systems

Created by
TWFScience

Create a classroom full of science detectives with this NO PREP, engaging, real-world investigation focused on blood types, transfusion compatibility, and immune system response. In this case file activity, students analyze laboratory results, examine transfusion reactions, track antibody pathways,

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Dehydration & Electrolyte Imbalance Mystery – Detective SUB PLAN

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on hydration, electrolyte balance, and whole-body system stability. In this case file activity, students analyze medical data, examine laboratory test results, track fluid and electrolyte pathway

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Immune System Breakdown Mystery – Detective SUB PLAN | Body Systems

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on immune system breakdown and whole-body health disruption. In this case file activity, students analyze laboratory reports, examine white blood cell counts, track stress hormone patterns, evalu

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Screen Time Addiction & Mental Health Mystery – Detective SUB PLAN |

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on screen time addiction and mental health disruption. In this case file activity, students analyze daily screen use data, examine dopamine reward responses, track sleep hormone disruption, evalu

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

When Will I Ever Use This? Reading | Grade 8 & Up | Solving Problems, Careers

Created by
TWFScience

Why We Need to Learn Science: Real-World Problem Solving, Careers, and Skilled Trades Reading Comprehension Passage and QuestionsThis reading answers the question we all get, "When am I ever Going to Use this?" This is a high-interest, real-world reading that helps students understand how science cl

8th - 12th Science, General Science, Physical Science

Also included in: Science Reading Comprehension Article Mega Bundle | Grade 8 and Up

Space Science Emergency Sub Plans | 2 Days | Middle School | No Prep Worksheets

Created by
TWFScience

2-Day, Emergency Space Science Introduction Sub Plans – No Prep 6th, 7th, 8th Grade Astronomy Activities and Worksheets.Need to be away from your classroom but still want your students to continue learning meaningful science content? This print-and-go AND fully digital 2-day Emergency Sub Plan allow

5th - 9th Astronomy, Earth Sciences, General Science

NGSS MS-ESS1-2, MS-ESS1-3, MS-ETS1-1

Our Solar System Emergency Sub Plans | 2 Days | Middle School | No Prep Space

Created by
TWFScience

2-Day, Emergency Solar System Sub Plans – No Prep 6th, 7th, 8th Grade Astronomy Activities and Worksheets.Need to be away from your classroom but still want your students to continue learning meaningful science content?This print-and-go AND fully digital 2-day Emergency Sub Plan allows your students

5th - 9th Astronomy, Earth Sciences, General Science

NGSS MS-ESS1-2, MS-ESS1-3, MS-ETS1-1