Middle School Biology Resources

The Autoimmune Disorder Mystery – Detective SUB PLAN | Immunity, Body Systems

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on immune system malfunction and autoimmune disorders. In this case file activity, students analyze laboratory data, examine inflammatory markers, evaluate antibody test results, track immune pat

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Blood Types Mystery – Detective SUB PLAN | ABO, Rh factor, Body Systems

Created by
TWFScience

Create a classroom full of science detectives with this NO PREP, engaging, real-world investigation focused on blood types, transfusion compatibility, and immune system response. In this case file activity, students analyze laboratory results, examine transfusion reactions, track antibody pathways,

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Dehydration & Electrolyte Imbalance Mystery – Detective SUB PLAN

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on hydration, electrolyte balance, and whole-body system stability. In this case file activity, students analyze medical data, examine laboratory test results, track fluid and electrolyte pathway

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Immune System Breakdown Mystery – Detective SUB PLAN | Body Systems

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on immune system breakdown and whole-body health disruption. In this case file activity, students analyze laboratory reports, examine white blood cell counts, track stress hormone patterns, evalu

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

The Screen Time Addiction & Mental Health Mystery – Detective SUB PLAN |

Created by
TWFScience

Turn your students into science detectives with this NO PREP, engaging, real-world investigation focused on screen time addiction and mental health disruption. In this case file activity, students analyze daily screen use data, examine dopamine reward responses, track sleep hormone disruption, evalu

7th - 11th Anatomy, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+4

Also included in: Science Detective Mystery Bundle | Chemistry, Human Body, Environmental Science

Environmental Science Data Investigation Bundle | Case Studies & Graphing

Created by
TWFScience

Turn your classroom into an environmental investigation lab.This growing bundle of Environmental Case Files gives students authentic, data-driven ecosystem challenges where they analyze trends, evaluate evidence, and determine the most likely cause of environmental change.These are not simple readin

6th - 9th Biology, Earth Sciences, General Science

NGSS MS-LS2-1, MS-LS2-2, MS-LS2-3+2

Coral Reef Bleaching | Environmental Science Data Investigation - Graphing & CER

Created by
TWFScience

Turn your classroom into a marine science investigation lab.In this Environmental Science Data Investigation, students analyze real-world style datasets to determine why corals in a reef ecosystem are turning white. Through graphing, trend analysis, and structured evidence evaluation, students uncov

6th - 9th Biology, Earth Sciences, Marine Science

NGSS MS-LS2-1, MS-LS2-2, MS-LS2-4+1

Also included in: Environmental Science Data Investigation Bundle | Case Studies & Graphing

Algae Bloom at Lake Greenwood | Environmental Data Investigation - Graphing, CER

Created by
TWFScience

In this Environmental Science Data Investigation, students analyze real-world style datasets to determine why a thick green algae bloom suddenly appeared in Lake Greenwood.Through graphing, trend analysis, and structured evidence evaluation, students uncover the most likely cause of the bloom.This i

6th - 9th Biology, Earth Sciences, Marine Science

NGSS MS-LS2-1, MS-LS2-2, MS-LS2-4+1

Also included in: Environmental Science Data Investigation Bundle | Case Studies & Graphing

The Cloudy Reservoir | Environmental Science Data Investigation - Graphing, CER

Created by
TWFScience

Turn your classroom into a water quality investigation lab.In this Environmental Science Data Investigation, students analyze real-world style datasets to determine why the city’s drinking water reservoir has become unusually cloudy.Through graphing, trend analysis, and structured evidence evaluatio

6th - 9th Biology, Earth Sciences, Marine Science

NGSS MS-LS2-1, MS-LS2-2, MS-LS2-4+1

Also included in: Environmental Science Data Investigation Bundle | Case Studies & Graphing

The Dying Wetland Plants | Environmental Data Investigation - Graphing, CER

Created by
TWFScience

Turn your classroom into a land ecosystem investigation lab.In this Environmental Science Data Investigation, students analyze real-world style datasets to determine why native plants in a local wetland are declining. Through graphing, trend analysis, and structured evidence evaluation, students unc

6th - 9th Biology, Earth Sciences, Marine Science

NGSS MS-LS2-1, MS-LS2-2, MS-LS2-4+1

Also included in: Environmental Science Data Investigation Bundle | Case Studies & Graphing

Fish Kill at Riverbend Creek | Environmental Data Investigation | Graphing, CER

Created by
TWFScience

Turn your classroom into a freshwater ecosystem investigation lab.In this Environmental Science Data Investigation, students analyze real-world style datasets to determine why fish suddenly died overnight near Riverbend Creek.Through graphing, trend analysis, and structured evidence evaluation, stud

6th - 9th Biology, Earth Sciences, Marine Science

NGSS MS-LS2-1, MS-LS2-2, MS-LS2-4+1

Also included in: Environmental Science Data Investigation Bundle | Case Studies & Graphing

Germ Theory Reading - Germs and the Immune System, Disease | 6th, 7th, 8th Grade

Created by
TWFScience

This grade 6–8 reading comprehension article and questions introduces students to germ theory—the scientific discovery that microorganisms cause many diseases. Students explore how this idea revolutionized medicine, changed hygiene practices, and continues to shape public health today. From the work

6th - 8th Anatomy, Biology, General Science

NGSS MS-LS1-2, MS-LS1-3

Also included in: Reading Comprehension Article & Question Mega Bundle | 6th, 7th, 8th Grade

Disease Spread & Public Health Data Graphing Labs | 6th, 7th, 8th Grade Science

Created by
TWFScience

These three disease spread and public health data graphing activities will help your students understand how infectious diseases spread and how prevention strategies impact public health while building strong graphing and data analysis skills. This bundle gives teachers an easy, NO PREP way to have

6th - 9th Graphing, Biology, General Science

NGSS MS-ESS2-1, MS-ESS2-2, MS-ESS2-3

Also included in: Middle School Science Graphing & Data Analysis Bundle | Real-World Data 6, 7, 8

Spring Environmental Data Graphing Lab Bundle | 6th, 7th, 8th Grade | Seasons

Created by
TWFScience

These three spring environmental change data graphing activities will help your students understand how seasonal climate conditions influence ecosystems while building strong graphing and data analysis skills. This bundle gives teachers an easy, NO PREP way to have students work with real-world envi

6th - 9th Graphing, Biology, General Science

NGSS MS-ESS2-1, MS-ESS2-4, MS-ESS2-6

Also included in: Middle School Science Graphing & Data Analysis Bundle | Real-World Data 6, 7, 8

Energy Transfer and Heat Investigation Graphing Lab Bundle | 6th, 7th, 8th Grade

Created by
TWFScience

These three energy transfer and heat graphing investigations help students understand how thermal energy moves through matter while building strong graphing and data analysis skills. This bundle gives teachers an easy, NO PREP way to have students work with real-world style datasets to explore Heati

6th - 9th Graphing, Biology, General Science

NGSS MS-PS3-3, MS-PS3-4

Also included in: Middle School Science Graphing & Data Analysis Bundle | Real-World Data 6, 7, 8

Middle School Science Graphing & Data Analysis Bundle | Real-World Data 6, 7, 8

Created by
TWFScience

This growing bundle of science data graphing investigations helps students explore major middle school science concepts while building strong graphing and data analysis skills. Each investigation uses real-world or real-world style datasets so students can analyze patterns, identify trends, and expl

6th - 9th Biology, Earth Sciences, General Science

NGSS MS-PS1-2, MS-PS2-1, MS-PS2-2+22

The Consequences of Sleep Deprivation Reading | Grade 8 & Up | Circadian Rhythm

Created by
TWFScience

The Consequences of Sleep Deprivation: Health, Learning, and Society Reading Comprehension Passage and QuestionsThis reading explores the real-world science behind sleep deprivation and how it affects the brain, body, and everyday life. It is a high-interest topic that helps students understand why

8th - 12th Biology, General Science, Other (Science)

Also included in: Science Reading Comprehension Article Mega Bundle | Grade 8 and Up

Antibiotic Resistance Reading | How Bacteria Evolve and Adapt | Grade 8 & Up

Created by
TWFScience

Antibiotic Resistance: Causes, Consequences, and Global Responses Reading Comprehension Passage and QuestionsThis reading explores the real-world science behind antibiotic resistance and how it impacts human health, healthcare systems, and global society. It is a high-interest topic that helps stude

8th - 12th Basic Principles, Biology, General Science

NGSS HS-LS4-1, HS-LS4-2, HS-LS4-3+2

Also included in: Science Reading Comprehension Article Mega Bundle | Grade 8 and Up

Design a Habitat & Ecosystem Project | 6th, 7th, 8th Grade

Created by
TWFScience

In this project, your students will explore how habitats support life and how organisms are specially adapted to survive in different environments. Students will design their own habitat, create 10 unique organisms with specific adaptations, and investigate how living and non-living factors interact

7th - 9th Biology, Earth Sciences, Environment

NGSS MS-PS2-1, MS-PS2-3

Water Pollution and Public Health Reading | Grade 8 & Up | Ecosystem Damage

Created by
TWFScience

Water Pollution: Sources, Health Risks, Ecosystem Damage, and Solutions Reading Comprehension Passage and QuestionsThis reading explores the real-world science behind water pollution and how it affects ecosystems, human health, and society. It helps students understand how pollutants enter water sys

8th - 12th Biology, Earth Sciences, Environment

NGSS MS-LS2-1, MS-LS2-4, MS-ESS3-1+7

Also included in: Human Impact & Sustainability - 13 Reading Comprehension Bundle | Grade 8 and Up

Deforestation and Habitat Destruction Reading | Grade 8 & Up | Biodiversity

Created by
TWFScience

Deforestation and Habitat Destruction Reading Comprehension Passage and QuestionsThis reading explores the real-world science behind deforestation and habitat destruction and how they affect biodiversity, climate, water systems, and human communities. It helps students understand why forests and oth

8th - 12th Biology, Earth Sciences, Environment

NGSS MS-LS2-1, MS-LS2-4, MS-ESS3-1+7

Also included in: Human Impact & Sustainability - 13 Reading Comprehension Bundle | Grade 8 and Up

Population Ecology Data Graphing Lab Bundle | 6th, 7th, 8th Population Dynamics

Created by
TWFScience

These three population ecology data graphing activities will help your students understand how predator and prey populations change over time, how resources affect carrying capacity, and how limiting factors such as food availability and disturbance affect population size while building strong graph

6th - 9th Graphing, Biology, Environment

NGSS MS-LS2-1, MS-LS2-2, MS-LS2-3+5

Also included in: Middle School Science Graphing & Data Analysis Bundle | Real-World Data 6, 7, 8

Human Body Systems Data Graphing Lab Bundle 6th, 7th, 8th Grade | Heart Rate

Created by
TWFScience

These three human body systems data graphing activities will help your students understand how heart rate changes during exercise, how breathing rate and oxygen use increase with activity, and how food energy and activity level are connected while building strong graphing and data analysis skills. T

6th - 9th Graphing, Biology, General Science

NGSS MS-LS1-3

Also included in: Human Body Systems - 5E Lesson Bundle | Cells, Tissues, Organs, Organ Systems

Human Body Systems - 5E Lesson Bundle | Cells, Tissues, Organs, Organ Systems

Created by
TWFScience

Human Body Systems Interactions - Fully editable and Complete 5E Lesson. This bundle is designed for middle school science students, but the content can be easily adapted to fit different learning levels.Lesson Objectives:Throughout this 5E lesson, students will learn about:Levels of organization in

6th - 9th Science, Biology, General Science

NGSS MS-LS1-1, MS-LS1-2, MS-LS1-3+1